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Answer from PP API Inc.

When do PrizePicks lines come out?

There is no fixed time, and it depends on the league. On our record the median NFL line appears 73 hours before the start, against 15 hours for the NBA.

Get free API keyProps by league
Pixel-art basketball centered on a court diagram.
LeagueMedian time before startLines measured
NBA15.2 hours67,193
NHL14.5 hours19,795
NFL3.0 days16,388
Soccer23.2 hours13,450
College Football2.2 days12,056
UCL40.2 hours7,994
MLS46.0 hours6,069
EPL2.5 days5,509
Serie A24.5 hours5,236
La Liga23.8 hours4,507
College Basketball18.7 hours4,352
Tennis16.6 hours4,216
From the first board check that showed each line to the scheduled start.

First seen means the first board check that showed the line, so the true posting time can be a few minutes earlier. Lines already up when recording began are left out. To catch new lines as they post, read offer.new events from the change feed.

New lines as events

Code
curl "https://prizepicksapi.com/api/v1/changes?league=NBA&limit=200" \
  -H "Authorization: Bearer $PRIZEPICKS_API_KEY"

Go further

Props by leagueStream consumersGET /api/v1/stream
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Independent data service, not affiliated with PrizePicks. Information only, not betting advice.